Registration Dossier
Registration Dossier
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EC number: 266-007-8 | CAS number: 65996-74-9 The oxidized surface of steel produced during reheating, conditioning, hot rolling, and hot forming operations. This substance is usually removed by process waters used for descaling, roll and material cooling, and other purposes. It is subsequently recovered by gravity separation techniques. Composed primarily of high-purity iron oxides. May contain varying amounts of other oxides, elements, and trace compounds.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Mill scale is mainly and primarily composed of high-purity iron oxides (on average above 65%, i.e. FeO, Fe2O3, Fe3O4). Besides, other metal oxides and spinels, elements, and trace compounds such as oil residues <1% for all the uses except for batteries and Melting charge for which <3% can be found in the mill scale. More information on the justification of read across can be found in the attached document in the endpoint summarie of section 7.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- diiron trioxide mixture
- IUPAC Name:
- diiron trioxide mixture
- Reference substance name:
- Bayferrox VP AC 5122 M (Fe2O3 83.5 %, FeO 12%, Co 4.5%)
- IUPAC Name:
- Bayferrox VP AC 5122 M (Fe2O3 83.5 %, FeO 12%, Co 4.5%)
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Two patches were shaved, one served as a control
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: each animal was evaluated individually
- Time point:
- other: 1, 24, ,48, 72 and 168 hrs
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No effects found at at any time point for any animal
- Irritation parameter:
- edema score
- Basis:
- other: each animal was evaluated individually
- Time point:
- other: 1, 24, 48, 72 and 168 hrs
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No edema was observed on any animal at any point in time
- Other effects:
- not observed
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Bayferrox VP AC 5122 M-Investigation of its primary irritation/corrosion on the rabbit skin. The test material is not irritating.
- Executive summary:
In a primary dermal irritation study 3 New Zealand white rabbits were dermally exposed to500 mgofBayferrox VP AC 5122 M (Fe2O3 83.5 %, FeO 12%, Co 4.5%) inwaterfor4hours. Animals then were observed for7days. The study was performed according to the OECD Guidelines 404 for acute dermal irritation/corrosion.Bayferrox VP AC 5122 M (Fe2O3 83.5 %, FeO 12%, Co 4.5%) did not causedermal irritation.
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