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EC number: 231-668-3 | CAS number: 7681-52-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Deficiencies: Yes. Only males were tested, duration of treatment only 1 hour, actual test atmosphere was not analytically determined, particle size was not determined, no batch number indicated. Although some aspects of the study do not meet up-to-date standards, the results are reliable and sufficient for risk assessment. New studies are not required and should not be conducted due to animal welfare considerations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Public avaialble literature. No guideline indicated. For details on method see materials and methods section in IUCLID5 dossier.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium hypochlorite
- EC Number:
- 231-668-3
- EC Name:
- Sodium hypochlorite
- Cas Number:
- 7681-52-9
- Molecular formula:
- ClO.Na
- IUPAC Name:
- sodium hypochlorite
- Details on test material:
- Sodium hypochlorite
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Age not stated, mean weight 177 g.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- Six male albino rats were exposed to an atmosphere containing 10.5 mg sodium hypochlorite/L for duration of 1 hour.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 10.5 mg/L
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- Six male albino rats were exposed to an atmosphere containing 10.5 mg sodium hypochlorite/L for duration of 1 hour. The animals were observed for signs of toxicity during exposure and for 14 days thereafter. Body weights were recorded at study initiation and termination. A gross necropsy was performed.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 10.5 mg/L air
- Exp. duration:
- 1 h
- Mortality:
- no mortality
- Clinical signs:
- other: Generalised inactivity, lacrimation
- Body weight:
- No significant findings
- Gross pathology:
- No significant findings
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Clinical signs included generalised inactivity and lacrimation. Gross autopsy did not reveal any significant findings.
The LC50 was determined to be greater than 10.5 mg/L.
Although the documentation appears to be of limited quality the applicant is of the opinion that all relevant data are available, all major issues
concerning acute inhalation toxicity are addressed and the annex point is sufficiently covered by this study. - Executive summary:
Materials and methods
Six male albino rats were exposed to an atmosphere containing 10.5 mg sodium hypochlorite/L for duration of 1 hour. The animals were observed for signs of toxicity during exposure and for 14 days thereafter. Body weights were recorded at study initiation and termination. A gross necropsy was performed.
Results and discussion
Clinical signs included generalised inactivity and lacrimation. Gross autopsy did not reveal any significant findings. The LC50 was determined to be greater than 10.5 mg/L.
Although the documentation appears to be of limited quality the applicant is of the opinion that all relevant data are available, all major issues concerning acute inhalation toxicity are addressed and the annex point is sufficiently covered by this study.
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