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EC number: 273-606-8 | CAS number: 68990-52-3
In an acute oral toxicity study (Kaysen A, 1984), groups of fasted, Sprague-Dawley Crl rats (5 males and 5 females) were given a single oral dose of metiloil A (batch No. 1169) at dose of 5 000 mg/kg bw and observed for 14 days. Oral LD0 (combined sex) is greater than 5000 mg/kg bw (limit test). No mortality was observed. From 10 minutes to 3 hours after administration, hypokinesia was noticed in all animals. Then, no clinical signs were observed. No effect on body weight was observed at the end of the observation period. Metiloil A is not classified based on the LD50 combined sex. This acute oral study is classified as acceptable. It does satisfy the guideline requirement (OECD 401) for an acute oral study in the rats.
All studies on the substance and on the category members from primary and secondary literature reported no effect at the tested doses of 2000 or 5000 mg/Kg/bw for both oral and dermal routes. Inhalation route is not relevant based on exposure consideration and physical chemical properties of the substance.
Classification is only relevant for LD50 < 2000 mg/kg from any route of exposure and none of the tests have indicated such a result.
No classification for acute toxicity is warranted under 67/548/EEC or Regulation 1272/2008.
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