Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
skin sensitisation: in vitro
Data waiving:
other justification
Justification for data waiving:
Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

In accordance with REACH Annex VII, column 2 adaptation, studies on skin sensitisation do not need to be conducted as members of the butenes category are flammable gases at room temperature. No studies have been conducted on skin sensitisation with the butenes category but there are no indications from repeat dose studies that any of the butenes cause skin sensitisation.

Respiratory sensitisation

Endpoint conclusion
Additional information:

No studies have been conducted on respiratory sensitisation with the members of the butenes category but there is no data to indicate that any of the butenes would cause respiratory sensitisation.

Justification for classification or non-classification


There is no indication that members of the butenes category cause skin or respiratory sensitisation and therefore, according to the EU and GHS/CLP criteria, the butenes do not require classification for sensitisation properties.