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EC number: 203-449-2
CAS number: 106-98-9
of 1-alkenes in tissues after the final 12 h exposure to 300 ppm
concentrations are in µmol/kg
factors for exhalatory loss of C2 -C4 1 -alkenes ranged from 1.00 to
levels of in haemoglobin adducts (N-(2-hydroxyalkyl)valine) and DNA
adducts (7-alkylguanine) in lymphocytes and liver after exposure of rats
values are subtracted
N = 3-8 for
haemoglobin and 4 for DNA adduct analysis
The absorption, distribution, elimination,
haemoglobin adduct formation and DNA adduct formation of individual
C2-C8 1-alkenes was studied in the rat after exposure to 300 ppm
(688mg/m3), 12 h a day for 3 consecutive days. The concentrations of the
alkenes were measured in blood, lung, brain, liver, kidney and
peri-renal fat immediately after each exposure and 12 h after the third
exposure. DNA adducts were determined by 32P-postlabeling in liver.
Haemoglobin adducts were determined in erythrocytes by GC/MS and
GC/MS/MS. Concentrations of 1-alkenes in blood and organs reached a
steady-state level after the first 12 h exposure, and the concentrations
12 h after the last exposure were generally low, except in fat.
Concentrations of 1-alkenes in blood and the different tissues increased
with increasing number of carbon atoms. However, DNA adducts and
haemoglobin adducts decreased with increasing number of carbon atoms
with the most pronounced decrease being from C2 to C3. The decrease in
haemoglobin adducts was more pronounced than DNA adducts. All 1-alkenes
caused formation of detectable levels of haemoglobin and DNA adducts,
although the levels of haemoglobin adducts after C4-C8 exposure were
low. These results also indicate that extrapolation within the
homologous series is possible.
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