Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study reported in EU-RAR 2006; reliability 2 assumed

Data source

Reference
Reference Type:
publication
Title:
Formaldehyde and phenol exposure during an anatomy dissection course: a possible source of IgE-mediated sensitization.
Author:
Wantke F, Focke M, Hemmer W, Tschabitscher M, Gann M, Tappler P, Gotz M, Jarisch R
Year:
1996
Bibliographic source:
Allergy 51, 837-841

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenol
EC Number:
203-632-7
EC Name:
Phenol
Cas Number:
108-95-2
Molecular formula:
C6H6O
IUPAC Name:
phenol

Method

Ethical approval:
not specified
Subjects:
- Number of subjects exposed: 45

Results and discussion

Results of examinations:
There is no evidence of allergic contact dermatitis caused by phenol. No specific Ig-E-reaction to phenol was measured for 45 students before and after a 4-week exposure to phenol during an anatomy course (no further details on the exposure)

Applicant's summary and conclusion