Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-632-7 | CAS number: 108-95-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Reliable study results are available from 8 long-term studies with six fish species. The tests were conducted under flow-through or semi-static conditions and the exposure concentrations were analytically verified in the six flow-through studies. In the semi-static tests (Verma et al. 1981, 1984) the interval for test water renewal was 24 h and the phenol concentrations are regarded as stable, since Colgan et al. (1982) demonstrated the stability of phenol under semi-static conditions (48 h interval).
The most sensitive endpoint was the NOEC of 77 µg phenol/L, based on nominal concentrations, obtained in a 60 day study with Cirrhina mrigala under semi-static conditions with a 24 hour renewal period (Verma et al 1984).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.077 mg/L
Additional information
The data on long term toxicity of phenol on fish is presented in EU RAR (2006) in Section 3.2.1 (Aquatic compartment (incl. Sediment), page 36ff).
Reliable study results are available from 8 long-term studies with six fish species. The tests were conducted under flow-through or semi-static conditions and the exposure concentrations were analytically verified in the six flow-through studies. In the semi-static tests (Verma et al. 1981, 1984) the interval for test water renewal was 24 h and the phenol concentrations are regarded as stable, since Colgan et al. (1982) demonstrated the stability of phenol under semi-static conditions (48 h interval).
The most sensitive endpoint was the NOEC of 77 µg/L, based on nominal concentrations, obtained in a 60 day study with Cirrhina mrigala under semi-static conditions with a 24 hour renewal period (Verma et al., 1984). At test end survival and wet weight of the surviving larvae was recorded. Based on these results a MATC of 77 - 94 µg/L was found and a NOEC of 77 µg/L was derived. This NOEC obtained with larvae of Cirrhina mrigala is confirmed by the 60 d NOEC of 110 µg/L obtained with Cyprinus carpio from the same authors (Verma et al., 1981).
The very sensitive embryo-larval tests conducted from Birge et al. (1979) and Black et al. (1982, 1983) had been evaluated and discussed within the framework of the EU RAR (2006) and it was decided by the EU member states not to use these data for a derivation of a PNECaqua if other valid fish early life stage tests are available. Following the discussions and conclusions of the EU RAR regarding the studies of Birge et al. and Black et al., they were not considered in the current hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
