Registration Dossier
Registration Dossier
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EC number: 231-143-9 | CAS number: 7440-33-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-03-25 to 2000-01-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Well document study following OECD Guideline 404 performed under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tungsten
- EC Number:
- 231-143-9
- EC Name:
- Tungsten
- Cas Number:
- 7440-33-7
- Molecular formula:
- W
- IUPAC Name:
- tungsten
- Reference substance name:
- Tungsten metal
- IUPAC Name:
- Tungsten metal
- Details on test material:
- - Name of test material (as cited in study report): Tungsten metal
- Appearance: Grey powder
- Purity: >99%
- Stored at room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, England
- Age at study initiation: 10-11 weeks
- Weight at study initiation: 2.3-2.6 kg
- Housing: stainless steel cages with perforated floors, Building R14, Room 4
- Diet: STANRAB (P) SQC , hay ad libitum
- Water: ad libitum
- Acclimation period: 6 days
- Female
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5- 22.0
- Humidity (%): 38-62%
- Air changes (per hr): 19/hr
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: distilled water
- Controls:
- not required
- Amount / concentration applied:
- 500 mg applied, 0.5mL distilled water added to gauze pad
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hrs: observations made at 60min, 24, 48 and 72 hours.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 25mm x 25mm (6.25 cm^2)
- Type of wrap if used: moistened gauze covered with "Elastoplast"
REMOVAL OF TEST SUBSTANCE
-After four hours site was washed with warm water, blotted dry with absorbent paper
SCORING SYSTEM: Intact skin was evaluated for erythema and edema after 1, 24, 48 and 72 hours on a scale of 0-4 for each effect.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- A single semi-occlusive application of Tungsten Metal Powder to intact rabbit skin for four hours elicited no dermal irritation over a 72-hour period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A single semi-occlusive application of Tungsten Metal Powder to intact rabbit skin for four hours elicited no dermal irritation over a 72-hour period.
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