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EC number: 203-806-2
CAS number: 110-82-7
of compound-related changes in clinical pathology parameters in male and
female mice exposed to cyclohexane
Red blood cells
* Statistically significant at p0.05 by Dunnett’s criteria
$ Significantly different from control at p0.05 by Mann-Whitney criteria
studies were conducted to determine the potential toxicity and/or
potential neurotoxicity of cyclohexane. Groups of mice were exposed to
0, 500, 2000, or 7000 ppm concentrations of cyclohexane vapour 6 hr/day,
5 days/week for 14 weeks. Subgroups were further observed during a
1-month recovery period. The NOEC for acute, transient effects was 500
ppm (1,720 mg/m3) (based on behavioural changes during
exposure at 2000 ppm and above). The NOAEC for subchronic toxicity in
mice is 2000 ppm (6,880 mg/m3) (based on haematological
changes at 7000 ppm).
It is of
note that there were no concomitant histological findings associated
with the liver weight effects reported at 7,000 ppm. These results were
not in accordance with those found during a two-week range finding test
(histological findings from 3,000 ppm and above in females and at 9,000
ppm in males). Consequently the reported NOAEC of subchronic toxicity is
considered to be very conservative since liver effects at 6,000 ppm
upwards could be viewed as adaptive in nature (as also concluded in the
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