Registration Dossier
Registration Dossier
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EC number: 203-742-5 | CAS number: 110-16-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review article data are considered to be from a trusted source
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicology of the eye, 3rd edition, p. 547
- Author:
- W.M. Grant
- Year:
- 1 986
- Bibliographic source:
- Springfield, IL, Charles C. Thomas
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Maleic acid
- EC Number:
- 203-742-5
- EC Name:
- Maleic acid
- Cas Number:
- 110-16-7
- Molecular formula:
- C4H4O4
- IUPAC Name:
- but-2-enedioic acid
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: rabbit
- Time point:
- other: 21 days
- Score:
- >= 1 - < 2
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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