Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
in vitro
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review article data are considered to be from a trusted source

Data source

Reference
Reference Type:
review article or handbook
Title:
Skin Corrosivity Potential of Fatty Acids: In Vitro Rat and Human Skin Testing and QSAR Studies
Author:
E. Whittle, M.D. Barratt, J.A. Carter, D.A. Basketter, M. Chamberlain
Year:
1996
Bibliographic source:
UK, Toxicology in Vitro, 10, p. 95-100

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Maleic acid
EC Number:
203-742-5
EC Name:
Maleic acid
Cas Number:
110-16-7
Molecular formula:
C4H4O4
IUPAC Name:
but-2-enedioic acid

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: TER Transcutaneous Electrical Resistance Assay
Basis:
animal: rat
Time point:
other: 24 hours
Score:
> 0 - < 5
Reversibility:
no data
Irritation parameter:
other: TER Transcutaneous Electrical Resistance Assay
Basis:
other: human
Time point:
other: 24 hours
Score:
> 0 - < 11
Reversibility:
no data

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS