Registration Dossier
Registration Dossier
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EC number: 232-379-5 | CAS number: 8011-76-5 Substance obtained by treating phosphate rock with sulfuric acid or a mixture of sulfuric and phosphoric acids. Composed primarily of calcium phosphates and calcium sulfate.
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- other: No data
Data source
Reference
- Reference Type:
- publication
- Title:
- A retrospective cohort mortality study of a phosphate fertilizer production facility.
- Author:
- Stayner, L.T., Meinhardt, T., Lemen, R., Bayliss, D., Herrick. R., Reeve, G.R., Smith, A.B., and Halperin, W.
- Year:
- 1 985
- Bibliographic source:
- Arch. Environ. Health 40:133-138.
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phosphate fertilizer
- IUPAC Name:
- Phosphate fertilizer
Constituent 1
Results and discussion
- Results:
- Overall, no statistically significant elevations in cause-specific mortality were observed for the entire study population. However, when the analysis was stratified by duration of employment and length of follow-up, a statistically significant (P < .05) excess in lung cancer mortality was observed among workers with more than 10 years of employment and follow-up (standardized mortality ratio = 411). Because of the small number of deaths involved, and because of a prior knowledge of a lung cancer cluster at this plant, the authors (NIOSH) state that these findings should be viewed as suggestive, and that other investigations in plants with similar exposures are needed to clarify whether an occupationally related lung cancer excess truly exists.
Applicant's summary and conclusion
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