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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
other: No data

Data source

Reference
Reference Type:
publication
Title:
A retrospective cohort mortality study of a phosphate fertilizer production facility.
Author:
Stayner, L.T., Meinhardt, T., Lemen, R., Bayliss, D., Herrick. R., Reeve, G.R., Smith, A.B., and Halperin, W.
Year:
1985
Bibliographic source:
Arch. Environ. Health 40:133-138.

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Phosphate fertilizer
IUPAC Name:
Phosphate fertilizer

Results and discussion

Results:
Overall, no statistically significant elevations in cause-specific mortality were observed for the entire study population. However, when the analysis was stratified by duration of employment and length of follow-up, a statistically significant (P < .05) excess in lung cancer mortality was observed among workers with more than 10 years of employment and follow-up (standardized mortality ratio = 411). Because of the small number of deaths involved, and because of a prior knowledge of a lung cancer cluster at this plant, the authors (NIOSH) state that these findings should be viewed as suggestive, and that other investigations in plants with similar exposures are needed to clarify whether an occupationally related lung cancer excess truly exists.

Applicant's summary and conclusion