Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In a key study conducted essentially according to OECD Guideline 429, tetrahydrofuran did not produce a three-fold or greater response in trititated thymidine incorporation and was thus rated negative in the mouse local lymph node assay (LLNA) whan administered neat (50 microliters/mouse) on each of 3 successive days. In supporting LLNA studies in mice, tetrahydrofuran was used as a vehicle control in 2 studies. Results, as dpm/node, were 805.28 and 745.21 dpm/node, respectively. Based on control data from the testing laboratory, these values were within historical control ranges. Tetrahydrofuran was judged to be a nonsensitiser in this study.


Migrated from Short description of key information:
Tetrahydrofuran was found to be negative when tested with the murine Local Lymph Node Assay (LLNA), and was used as a solvent control in at least two additional LLNA studies, again with no evidence of sensitising properties.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Migrated from Short description of key information:
Tetrahydrofuran has not been specifically tested for respiratory sensitisation, but as multiple studies on skin sensitisation have been negative and the compound contains no functional groups of concern, THF is not expected to present any respiratory sensitisation hazard.

Justification for classification or non-classification