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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
other: supplemental information
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Altered Developmental Toxicity Caused by Three Carrier Solvents.
Author:
Rayburn, J.R., DeYoung, D.J., Bantle, J.A.
Year:
1991
Bibliographic source:
Journal of Applied Toxicology Vol. II(4), 253-260

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-(ethylenedioxy)diethanol
EC Number:
203-953-2
EC Name:
2,2'-(ethylenedioxy)diethanol
Cas Number:
112-27-6
Molecular formula:
C6H14O4
IUPAC Name:
2-[2-(2-hydroxyethoxy)ethoxy]ethan-1-ol
Test material form:
liquid

Results and discussion

Any other information on results incl. tables

The test substance only increased the mortality and malformation with TCE. There were additive effects for growth for all solvents with the teratogens. The carrier solvents caused interactions even at their NOEC.

Applicant's summary and conclusion