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Diss Factsheets
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EC number: 203-953-2 | CAS number: 112-27-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached justification document 'update_Category Justification_ethylene glycol and higher glycols_2022.doc'
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
See above.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See above.
3. ANALOGUE APPROACH JUSTIFICATION
See above.
4. DATA MATRIX
See above. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- CAS 4792-15-8, Mead & McKenzie, 2003
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
Estimation Programs Interface (EPI) Suite for Microsoft Windows, v4.11 (US EPA, 2012)
2. MODEL (incl. version number)
ECOSAR v2.00
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See section 'Test Material'.
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached QMRF.
5. APPLICABILITY DOMAIN
See attached QPRF.
6. ADEQUACY OF THE RESULT
- The model is scientifically valid (see attached QMRF).
- The model estimates the toxicity to aquatic organisms: Daphnids: 48-h EC50; this data can be used to support the assessment regarding the toxicity of a substance to
aquatic organisms (see also attached QPRF). - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- ECOSAR v2.00: Estimation of acute and chronic toxicity to green algae for chemical class "Neutral Organic SAR (Baseline Toxicity)"
- GLP compliance:
- no
- Test organisms (species):
- other: green algae
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 20 518 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- act. ingr.
- Basis for effect:
- not specified
- Remarks on result:
- other: ECOSAR chemical class: "Neutral Organic SAR (Baseline Toxicity)"; The substance is in the applicability domain of the model.
- Dose descriptor:
- other: Chronic Value (ChV)
- Effect conc.:
- 2 486 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- act. ingr.
- Basis for effect:
- not specified
- Remarks on result:
- other: ECOSAR chemical class: "Neutral Organic SAR (Baseline Toxicity)"; The substance is in the applicability domain of the model.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached justification document 'update_Category Justification_ethylene glycol and higher glycols_2022.doc'
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
See above.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See above.
3. ANALOGUE APPROACH JUSTIFICATION
See above.
4. DATA MATRIX
See above. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 6 500 - < 13 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- CAS 107-21-1, Dow Chemical, 1982
Referenceopen allclose all
Description of key information
From the available test data for the substance and its structurally similar compound in combination with the reliable QSAR calculation it can be concluded, that the substance is with high probability acutely not harmful to algae
Key value for chemical safety assessment
Additional information
Since no experimental data are available for the test substance, read-across approach with two structurally similar substances was performed. The experimental data on the toxicity for aquatic algae are available for two structurally similar substances ethylene glycol (CAS 107 -21 -1) and pentaethylene glycol (CAS 4792 -15 -8).
The key study according to OECD guideline 201 is availablefor pentaethylene glycol. In this study the green algae Pseudokirchnerella subcapitata was exposed for 72 hours in a limit test with a test concentration of 100 mg/L. No effects on the growth rate of the algae were determined (Mead & McKenzie, 2003 – cited in OECD SIDS, 2004).
For ethylene glycol a further study with Selenastrum capricornutum is available, which was conducted according to EPA standards. After 96 hours of exposure an EC50 value of 6500-13000 mg/L is reported (Dow, 1982).
These results are supported with the estimated value for the test substance itself, wich was derived for the test substance itself from a valid QSAR model (ECOSAR v2.0; BASF SE, 2022). The 72 -h EC50 for the substance was predicted to be 20518 mg/L.The calculated chronic value (ChV) for 2 ,2'-(ethylenedioxy)diethanol is 2486 mg/L.The substance was within the applicability domain of the model.
From the available estimated test data for the substance and the availbale experimental data for its structurally similar compounds it can be concluded, that the substance is with high probability acutely not harmful to algae
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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