Registration Dossier
Registration Dossier
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EC number: 231-826-1 | CAS number: 7757-93-9
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Follows basic scientific principles. Not a toxicological study, but provides supporting data to suggest the inorganic phosphates tested are tolerated in the diets of mammals.
Data source
Reference
- Reference Type:
- publication
- Title:
- Energy and Phosphorus Status as Factors Affecting Postpartum Performance and Health of Dairy Cows
- Author:
- Carstairs JA, Neitzel RR and Emery RS
- Year:
- 1 981
- Bibliographic source:
- Journal of Dairy Science. 64(1)
Materials and methods
- Type of study / information:
- Information on the use of phosphates as food additives for animals.
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium hydrogenorthophosphate
- EC Number:
- 231-826-1
- EC Name:
- Calcium hydrogenorthophosphate
- Cas Number:
- 7757-93-9
- Molecular formula:
- CaHPO4
- IUPAC Name:
- calcium hydrogen phosphate
- Details on test material:
- - Name of test material (as cited in study report): dicalcium phosphate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- To determine if energy and phosphorus status would affect postpartum health and lactational performance, first-calf heifers were assigned at parturition, 12 per group, to either high (135% of requirement) or low (85% of requirement) energy, high (138% of requirement) or adequate (98% of requirement) phosphorus in a 2 × 2 factorial design. Treatments extended 84- days postpartum after which standard rations were fed. Milk yields were similar until wk 5 of lactation. From wk 5 to 12, cows fed adequate phosphorus (98% of requirement) yielded 1.8 kg/day more milk than high phosphorus groups. Energy did not affect milk yield until wk 9 when persistency of low energy groups declined. High energy groups had almost twice as much disease and higher rectal temperatures than low energy groups in the first 3 mo of lactation. All heifers had temperatures above expected during the 1st mo of lactation. Excess energy should be avoided for the 1st mo of lactation and then gradually increased. Phosphorus should be fed as recommended and no more.
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