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EC number: 215-535-7 | CAS number: 1330-20-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, near guideline study, published in peer reviewed literature, limitations in design and/or reporting but otherwise adequate for assessment.
- Justification for type of information:
- N/A
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Single oral dose followed by 14 day observation period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- m-xylene
- EC Number:
- 203-576-3
- EC Name:
- m-xylene
- Cas Number:
- 108-38-3
- Molecular formula:
- C8H10
- IUPAC Name:
- m-xylene
- Details on test material:
- no further details
Constituent 1
- Specific details on test material used for the study:
- not specified
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Age: 4-5 weeks. Body weight: 90-120 g. Non-fasted.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Single dose
- Doses:
- Logarithmic differing by a factor of 2 (no further details)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days.
- Statistics:
- Oral LD50 (and its fiducial range) estimated. Methods used are not detailed (probit analysis assumed).
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 631 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 366 - 8 196
- Remarks on result:
- other: 7.71 mL/kg bw and adjusted for density of 0.86
- Mortality:
- not specified
- Clinical signs:
- other: other: not specified
- Gross pathology:
- not specified
- Other findings:
- N/A
Any other information on results incl. tables
N/A
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 of m-xylene in male rats was 6602 mg/kg.
- Executive summary:
The acute oral LD50 of m-xylene in male rats was 7.71 mL/kg bodyweight (95% CI = 6.24-9.53 mL/kg bw) equivalent to 6602 mg/kg.
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