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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Already evaluated by the Competent Authority for Biocides.

Data source

Reference
Reference Type:
publication
Title:
Copper in drinking water: not a strong risk factor for diarrhoea among young children. A population-based from Sweden
Author:
R. Pettersson; F. Rasmussen and A. Oskarsson
Year:
2003
Bibliographic source:
Acta Paediatr 92: 473-480, 2003 [Taylor & Francis, ISSN 0803-5253]

Materials and methods

Type of study / information:
See Executive summary
Endpoint addressed:
repeated dose toxicity: oral
Test guideline
Qualifier:
no guideline available
Deviations:
not applicable
Principles of method if other than guideline:
No guidelines available. The Swedish Data Inspection Board and the committees for research ethics at Uppsala University and Lund University
approved this study.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
See Executive summary

Method

Ethical approval:
confirmed, but no further information available
Details on study design:
See Executive summary
Exposure assessment:
measured
Details on exposure:
See Executive summary

Results and discussion

Results:
See Executive summary

Any other information on results incl. tables

See attached

Applicant's summary and conclusion

Conclusions:
See Executive summary
Executive summary:

Aim:

To assess whether mean daily intake of copper or maximal concentration of copper in drinking water is related to the incidence of diarrhoea and vomiting among young children.

Methods:

Mean daily intake of copper in drinking water was estimated prior to episodes of diarrhoea among 430 children aged 9 to 21 months. A total of 4703 samples of tap water were collected in the homes of the children. The mean daily intake of copper and the maximal concentration of copper in samples of consumed water were used as measures of exposure. The cumulative incidence of acute diarrhoea and vomiting was studies during a 12 wk follow up. Cases of diarrhoea caused by viral and bacterial infections were identified.

Results:

The median copper level of the mean value for each child was 0.61 mg/l with 10thand 90thpercentiles of 0.04 and 1.57 mg/l. Among the 430 children, 43 had episodes of acute diarrhoea, of which 23 had no identified viral or bacterial origin and vomiting was reported in 95 children. No significant associations were found between daily intake of copper or maximal concentration of copper in drinking water and risk of diarrhoea or vomiting.

Conclusion:

There is unlikely to be a strong association between daily intake of copper or maximal concentration of copper in drinking water and the risk of diarrhoea or vomiting within the range of copper intakes/concentrations studied.