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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1968
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Included for completion purposes only. Study not fully reviewed as waiver available for this end point.

Data source

Reference
Reference Type:
publication
Title:
"Horny layer injury by solvents".
Author:
Malten KE; Spruit D; Boemaars HG; Keizer M.J.
Year:
1968
Bibliographic source:
Berufsdermatosen 16, 135 - 147

Materials and methods

Type of study / information:
Type of experience: Human
Endpoint addressed:
dermal absorption
skin irritation / corrosion
Principles of method if other than guideline:
Assessment of damage caused to skin barrier properties by measuring transdermal water loss after skin exposure to solvent.

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl acetate
EC Number:
205-500-4
EC Name:
Ethyl acetate
Cas Number:
141-78-6
Molecular formula:
C4H8O2
IUPAC Name:
ethyl acetate

Results and discussion

Applicant's summary and conclusion

Executive summary:

A study reported that application of ethyl acetate to (probably) three volunteers for 1 h/d for 6 days resulted in damage to the outer skin layer (stratum corneum), as measured by an increase in the rate of water vapour loss from the skin.