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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1968
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Included for completion purposes only. Study not fully reviewed as waiver available for this end point.

Data source

Reference
Reference Type:
publication
Title:
"Horny layer injury by solvents".
Author:
Malten KE; Spruit D; Boemaars HG; Keizer M.J.
Year:
1968
Bibliographic source:
Berufsdermatosen 16, 135 - 147

Materials and methods

Type of study / information:
Type of experience: Human
Endpoint addressed:
dermal absorption
skin irritation / corrosion
Principles of method if other than guideline:
Assessment of damage caused to skin barrier properties by measuring transdermal water loss after skin exposure to solvent.

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Executive summary:

A study reported that application of ethyl acetate to (probably) three volunteers for 1 h/d for 6 days resulted in damage to the outer skin layer (stratum corneum), as measured by an increase in the rate of water vapour loss from the skin.