Registration Dossier
Registration Dossier
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EC number: 205-500-4 | CAS number: 141-78-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original study cited not reviewed. Included for completion only using information from a secondary source.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Human patch testing
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl acetate
- EC Number:
- 205-500-4
- EC Name:
- Ethyl acetate
- Cas Number:
- 141-78-6
- Molecular formula:
- C4H8O2
- IUPAC Name:
- ethyl acetate
- Details on test material:
- Formulation containing 97% ethyl acetate.
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 25
- Route of administration:
- dermal
Results and discussion
Any other information on results incl. tables
A challenge test 10 days after the final induction patch failed to elicit any skin reactions
Applicant's summary and conclusion
- Executive summary:
The skin sensitization potential of a formulation containing 97% ethyl acetate has been evaluated in human repeated insult patch testing. Twenty-five subjects were patch-tested with 0.3 ml under occlusive conditions for five consecutive 48 -hr periods. A challenge test 10 days after the final induction patch failed to elicit any skin reactions.
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