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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

NOEC (32 day) <9.65mg/l (growth), >75.6mg/l (hatching, survival)
NOEC (32 day) =6.9mg/l (QSAR)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
6.9 mg/L

Additional information

The effects of chronic ethyl acetate exposure to Pimephales promelas (Fathead minnow) have been studied. Ethyl acetate was studied in a fish early life stage test where hatching of embryos followed by 32 -day early life stage growth of fry was assessed. The most sensitive response was growth, which was reduced(P< 0.05) at the lowest concentration tested (9.65 mg/L). However, the relationship between growth and toxicant concentration in the test was not clearly dose-related, with the greatest reduction in growth (47%) occurring at the two lowest exposure concentrations. The results do not allow a clear NOEC to be established, but it is clear that ethyl acetate is not a potent chronic toxicant; at 75mg/l, no mortality or adverse impact on hatching was seen, no mortality is evidence, and growth retardation was only reduced by 13% by length compared to controls. Based on the result however, it is reasonable to concur with the authors and conclude that the study shows a NOEC<9.65mg/l. This can be considered a conservative approach. This study is supported by a reliable QSAR which estimates that the NOEC would be 6.9mg/l for a study of the same duration, which is very consistent with the experimental data. As a conservative approach the NOEC value from the QSAR, the lower of the two values, is used as the NOEC for this end point.