Registration Dossier
Registration Dossier
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EC number: 205-500-4 | CAS number: 141-78-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
All values static and nominal concentrations or unknown unless specified:
P. Promelas LC50: 96hr: 230 (flow through, measured concentrations). 48hr: 270, >76mg/l (flow through)
L. Idus: LC50: 48hr: 333 mg/l
P reticulate: 48hr: 210mg/l
O Latipes: 48hr 125mg/l (not reliable), 900mg/l
S Gairdneri: 96hr: 230, 425, 484mg/l
H fossilis: 96hr; 213mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 230 mg/L
Additional information
There is data available on 6 fish species, a number of which have multiple studies available.
Two flow through studies with Pimephales promelas (Fathead minnow) were conducted using EPA methodology. The first study reported a 96-hr LC50 of 230 mg/L and 95% CLs were 220 to 250 mg/L. The second study reported no effects on larval fish survival within 96 hr at the highest concentration tested, 75.6 mg/l; therefore, no definitive LC50 was determined. Using static exposure conditions, a 96 -hr LC50 value of 212.5 mg ethyl acetate/L was reported in Heteropneustes fossilis (Catfish); 63.89 mg/L was considered to be a NOEC. A number of other studies have reported similar or higher acute toxicity values for ethyl acetate in fish.
Another study reported a 48 -hr, static LC50 value of 210 mg/L for ethyl acetate in Poecilia reticulata (Guppy), although only limited information are available about this study. One study reported a 48 -hr LC50 value of 125 mg/L for ethyl acetate in Oryzias latipes (Medaka); however insufficient information is published to judge the reliability of this result and another study in the same species reported an LC50 of 900mg/l.
The most reliable study is the one using the flow through methodology and measured concentrations. This reported an LC50 towards the lower range of those values reported. However, it should be noted that in general the reported LC50 values across 6 species and even more studies span a remarkably narrow range of values, indicating that toxicity is probably due to narcosis rather than a specific toxic effect .
There is no data available on salt water species although the life cycle of O latipes spans both salt and freshwater.
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