Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: A substantial publication collating hydrolysis data on a large number of substances, based on an extensive literature review or original experimental data. References given. Considered a reliable source of information.

Data source

Reference
Reference Type:
publication
Title:
Critical Review of Hydrolysis of Organic Compounds in Water Under Environmental Conditions
Author:
Mabey, W., Mill, T.
Year:
1978
Bibliographic source:
J. Phys. Chem. Ref. Data 7, 383 - 41

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Literature review of experimentally derived data.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): no data
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No data
Radiolabelling:
not specified

Study design

Analytical monitoring:
not required
Positive controls:
not specified
Negative controls:
not specified

Results and discussion

Transformation products:
not measured
Dissipation DT50 of parent compoundopen allclose all
pH:
5
Temp.:
24.9 °C
Hydrolysis rate constant:
0.04 a-1
DT50:
16 yr
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Hydrolysis rate constant 1.36E-9 s-1
pH:
7
Temp.:
24.9 °C
Hydrolysis rate constant:
0.35 a-1
DT50:
24 mo
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Hydrolysis rate constant 1.09E-8 s-1
pH:
9
Temp.:
24.9 °C
Hydrolysis rate constant:
0.09 d-1
DT50:
7.5 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Hydrolysis rate constant 1.07E-6 s-1

Any other information on results incl. tables

First order rate constant for: neutral hydrolysis: 1.5E-10 s-1

acid catalyzed hydrolysis: 1.1E-11 s-1

base catalyzed hydrolysis: 1.1E-8 s-1

Values as published by Skrabal A et al (Monatsh Chem, 50, 369, 1928)

First order rate constant for: neutral hydrolysis: 1.53E-10 s-1

acid catalyzed hydrolysis: 1.097E-4 M-1s-1

base catalyzed hydrolysis: 0.1077 M-1s-1

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
The substance is effectively stable to degradation by hydrolysis .under any environmental conditions likely to be experienced
Executive summary:

In a review of the hydrolysis rate constants of a wide number of organic compounds, data on ethyl acetate was reported which suggested that the substance is effectively resistant to hydrolysis under neutral and acid conditions but that under increasingly basic conditions, hydrolysis increasingly occurs. At pH9, the half life for hydrolysis is 7.5 days compared to 2 years under neutral pH conditions.