Dodecan-1-ol

Toxicity to birds

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

long-term toxicity to birds

Remarks:

long-term or reproductive testing

Data waiving:

other justification

Justification for data waiving:

other:

Reference 2

Endpoint:

short-term toxicity to birds: acute oral toxicity test

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable.

Qualifier:

no guideline followed

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 223 (Avian Acute Oral Toxicity Test)

Deviations:

not applicable

GLP compliance:

not specified

Dose method:

feed

Analytical monitoring:

not specified

Vehicle:

no

Test organisms (species):

other: Gallus gallus domesticus

Details on test organisms:

TEST ORGANISM

- Common name: chicken
TEST ORGANISM

- Common name: chicken

- Age at test initiation (mean and range, SD): 1 d

Limit test:

no

Total exposure duration (if not single dose):

21 d

Control animals:

not specified

Reference substance (positive control):

not specified

Duration (if not single dose):

21 d

Dose descriptor:

LD50

Effect level:

176 000 other: ppm

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Reported statistics and error estimates:

Median lethal dietary level

The US EPA is a peer reviewed online database source for ecotoxicological studies conducted globally. While full details on the study are not reported, the database does provide an indication of the study that was conducted. In this case the study is only supporting therefore full details are not required.

Validity criteria fulfilled:

not specified

Conclusions:

A reliable 21 day LD50 value of 176000 ppm has been determined for the effects of dodecanol on the mortality of the bird Gallus domesticus. Full details of the study are not available.

Additional information

Short-term toxicity

Only short term oral toxicity data to birds exists. A 21 day LC₅₀ value of 176000 ppm has been determined for the effects of dodecanol on mortality of Gallus domesticus (chicken). The study reflects the only value available with this substance for this endpoint.

However this study has not been selected as key since ECHA (2011, Guidance on information requirements and chemical safety assessment Part B: Hazard Assessment Dec 2011, version 2.1) reads: "due to poor correlation between short and long term effects, only long term studies are considered suitable for CSA purposes".

 

Long-term toxicity

In accordance with Column 2 of REACH Annex X, studies on long-term or reproductive toxicity to birds (required in section 9.6.1) do not need to be conducted due to the existence of mammalian data demonstrating no long term systemic effects to higher organisms. Secondary poisoning assessment is not required for this substance because the substance is readily biodegradable, the potential for bioaccumulation is low (BCF = 85 L/kg) and mammalian toxicity data indicate that the substance does not have a potential to cause toxic effects if accumulated in higher organisms.