Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-982-0 | CAS number: 112-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to birds
- Remarks:
- long-term or reproductive testing
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable.
- Qualifier:
- no guideline followed
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 223 (Avian Acute Oral Toxicity Test)
- Deviations:
- not applicable
- GLP compliance:
- not specified
- Dose method:
- feed
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- other: Gallus gallus domesticus
- Details on test organisms:
- TEST ORGANISM
- Common name: chicken
TEST ORGANISM
- Common name: chicken
- Age at test initiation (mean and range, SD): 1 d - Limit test:
- no
- Total exposure duration (if not single dose):
- 21 d
- Control animals:
- not specified
- Reference substance (positive control):
- not specified
- Duration (if not single dose):
- 21 d
- Dose descriptor:
- LD50
- Effect level:
- 176 000 other: ppm
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Reported statistics and error estimates:
- Median lethal dietary level
- Validity criteria fulfilled:
- not specified
- Conclusions:
- A reliable 21 day LD50 value of 176000 ppm has been determined for the effects of dodecanol on the mortality of the bird Gallus domesticus. Full details of the study are not available.
Referenceopen allclose all
The US EPA is a peer reviewed online database source for ecotoxicological studies conducted globally. While full details on the study are not reported, the database does provide an indication of the study that was conducted. In this case the study is only supporting therefore full details are not required.
Description of key information
Key value for chemical safety assessment
Additional information
Short-term toxicity
Only short term oral toxicity data to birds exists. A 21 day LC50 value of 176000 ppm has been determined for the effects of dodecanol on mortality of Gallus domesticus (chicken). The study reflects the only value available with this substance for this endpoint.
However this study has not been selected as key since ECHA (2011, Guidance on information requirements and chemical safety assessment Part B: Hazard Assessment Dec 2011, version 2.1) reads: "due to poor correlation between short and long term effects, only long term studies are considered suitable for CSA purposes".
Long-term toxicity
In accordance with Column 2 of REACH Annex X, studies on long-term or reproductive toxicity to birds (required in section 9.6.1) do not need to be conducted due to the existence of mammalian data demonstrating no long term systemic effects to higher organisms. Secondary poisoning assessment is not required for this substance because the substance is readily biodegradable, the potential for bioaccumulation is low (BCF = 85 L/kg) and mammalian toxicity data indicate that the substance does not have a potential to cause toxic effects if accumulated in higher organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
