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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to birds

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Administrative data

Link to relevant study record(s)

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long-term toxicity to birds
long-term or reproductive testing
Data waiving:
other justification
Justification for data waiving:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable.
no guideline followed
equivalent or similar to guideline
OECD Guideline 223 (Avian Acute Oral Toxicity Test)
not applicable
GLP compliance:
not specified
Dose method:
Analytical monitoring:
not specified
Test organisms (species):
other: Gallus gallus domesticus
Details on test organisms:

- Common name: chicken

- Common name: chicken

- Age at test initiation (mean and range, SD): 1 d
Limit test:
Total exposure duration (if not single dose):
21 d
Control animals:
not specified
Reference substance (positive control):
not specified
Duration (if not single dose):
21 d
Dose descriptor:
Effect level:
176 000 other: ppm
Conc. / dose based on:
test mat.
Basis for effect:
Reported statistics and error estimates:
Median lethal dietary level

The US EPA is a peer reviewed online database source for ecotoxicological studies conducted globally. While full details on the study are not reported, the database does provide an indication of the study that was conducted. In this case the study is only supporting therefore full details are not required.

Validity criteria fulfilled:
not specified
A reliable 21 day LD50 value of 176000 ppm has been determined for the effects of dodecanol on the mortality of the bird Gallus domesticus. Full details of the study are not available.

Description of key information

Key value for chemical safety assessment

Additional information

Short-term toxicity

Only short term oral toxicity data to birds exists. A 21 day LC50 value of 176000 ppm has been determined for the effects of dodecanol on mortality of Gallus domesticus (chicken). The study reflects the only value available with this substance for this endpoint.

However this study has not been selected as key since ECHA (2011, Guidance on information requirements and chemical safety assessment Part B: Hazard Assessment Dec 2011, version 2.1) reads: "due to poor correlation between short and long term effects, only long term studies are considered suitable for CSA purposes".


Long-term toxicity

In accordance with Column 2 of REACH Annex X, studies on long-term or reproductive toxicity to birds (required in section 9.6.1) do not need to be conducted due to the existence of mammalian data demonstrating no long term systemic effects to higher organisms. Secondary poisoning assessment is not required for this substance because the substance is readily biodegradable, the potential for bioaccumulation is low (BCF = 85 L/kg) and mammalian toxicity data indicate that the substance does not have a potential to cause toxic effects if accumulated in higher organisms.