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EC number: 203-982-0 | CAS number: 112-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- No details are available on the guideline used to determine this result.
- GLP compliance:
- not specified
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 5.36
- Conclusions:
- A log Kow value of 5.36 was reported for the substance.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Value obtained from a recognised source of physico-chemical data. This reference is considered as definitive for octanol-water partition coefficient values.
- Principles of method if other than guideline:
- No details are available on the guideline used to determine this result.
- GLP compliance:
- not specified
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 5.13
- Remarks on result:
- other: The pH at which the log Kow was measured is not stated, but it is consistent with expected properties of the substance in its non-ionised state. The temperature is not stated.
- Conclusions:
- A partition coefficient (log Kow) value of 5.13 was reported in a collection of reliable data which has been subject to peer-review . The result is considered to be reliable.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-04-30
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods (OECD) without GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 5.4
- Temp.:
- 23 °C
- pH:
- 7.1
- Remarks on result:
- other: Result for the dodecan-1-ol constituent of this multi-constituent test substance.
- Conclusions:
- A log Kow value of 5.4 at 23°C and pH 7.1 was obtained for the substance using a relevant test method. The result is considered to be reliable.
- Executive summary:
Alcohols, C12 -14 was determined according OECD Guideline 117. The partition coefficient of Dodecan-1 -ol was determined to be log Pow 5.4 at 23 °C and a pH of 7.1.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2010-10-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods (ASTM) without GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM E 1147
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 4.8
- Conclusions:
- A log Kow value of 4.8 was obtained for the substance using a relevant test method. The result is considered reliable.
- Executive summary:
Dodecan-1 -ol was determined according ASTM E 1147. The partition coefficient was determined to be log Pow 4.8.
Referenceopen allclose all
Calibration
For calibration 20 -30 mg of the reference samples and of thio urea (dead time determination) are weighed into a 100 ml volumetric flask and filled up to 100 ml of a methanol-water mixture (80:20). This calibration mixture (L090443) is then analysed by the reported chromatographic conditions.
substances | log Pow | retention time (min.) | capacity factor k | log k |
phenylbenzoate | 3.6 | 2.13 | 0.593 | -0.23 |
diphenyl ether | 4.2 | 2.63 | 0.964 | -0.02 |
dibenzyl | 4.8 | 3.90 | 1.913 | 0.28 |
flouranthene | 5.1 | 4.86 | 2.633 | 0.42 |
triphenylamine | 5.7 | 6.07 | 3.538 | 0.55 |
correlation log k and Pow
slope: 2.52
axis intercept: 4.17
correlation coefficient: 0.991
Measurement
200 -300 mg of the test sample are weighed into a 100 ml volumetric flask and filled up to 100 ml with methanol.
retention time (minutes) for C12: 5.61
peak area for C12: 222137
capacity factor for C12: 3.19
log k for C12: 0.50
log POW for C12: 5.4
retention time (minutes) for C14: 11.56
peak area for C14: 80213
capacity factor k for C14: 7.64
log k for C14: 0.88
log POW for C14: 6.4
Measurement
Log Pow: 4.8
Description of key information
The octanol-water partition coefficient of a commercial dodecan-1-ol product is 5.4 (by HPLC method).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.4
- at the temperature of:
- 23 °C
Additional information
The log octanol/water partition coefficient of 5.4 at 23°C and pH 7.1 was determined for the dodecan-1 -ol constituent in a study with Alcohols C12 -14 in accordance with OECD 117. The result is considered to be reliable.
It is supported by a reliable value of 5.13, believed to have been determined in a shake-flask test (Hansch et al, 1995); a reliable value of 5.36, taken from a reliable reference source for partitioning data (Burkhard, 1985, by HPLC). A value of 4.8 is available from a second reliable study.
The value taken from literature for pure alcohol is used in exposure modelling.
Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:
As chain length increases, the free energy required for a molecule to dissolve becomes less favourable for larger molecules. The octanol-water partition coefficient increases with molecular weight because each additional -CH2- group makes the octanol phase more preferred over water in terms of relative solvation energy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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