Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-554-3 | CAS number: 7631-99-4
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other:
- Title:
- Nitrate WHO Food Additives Series
- Author:
- World Health Organization (WHO)
- Year:
- 1 996
- Bibliographic source:
- World Health Organization (WHO)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium nitrate
- EC Number:
- 231-554-3
- EC Name:
- Sodium nitrate
- Cas Number:
- 7631-99-4
- Molecular formula:
- HNO3.Na
- IUPAC Name:
- sodium nitrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Physical appearance: not indicated
- Purity: not indicated
- Batch No.: not indicated
- Supplier: not indicated
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- C57BL
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 15 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 50 and 100 mg/kg bw/day
- No. of animals per sex per dose:
- not indicated
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- other: Cytogenetic and pathohistological changes of the spleen, liver and kidneys
- Sex:
- male
- Remarks on result:
- other:
- Remarks:
- Effect levels not determined
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
A moderate increase in the number of macrophages was observed in the spleen of treated animals. The kidneys showed alterations such as damaged small canals in the cortical part reflected by dystrophic cells, cytoplasm filled with small grains and missing or limited nuclei. In the liver, cell effects analogous to the ones in the kidneys were observed. These effects were reversible. |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
