Registration Dossier
Registration Dossier
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EC number: 231-554-3 | CAS number: 7631-99-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The reliability and summary were made based on the HPV program adopted during OECD SIAM 25 (October 2007).
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of sodium nitrate aerosol on cardiopulmonary function of dogs, sheep, and man.
- Author:
- Sackner, M.A., Dougherty, R.D., Chapman, G.A., Zarzecki, S., Zarzemski, L., and Schreck, R.
- Year:
- 1 979
- Bibliographic source:
- Environmental Research 18:421-436.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Sodium nitrate
- EC Number:
- 231-554-3
- EC Name:
- Sodium nitrate
- Cas Number:
- 7631-99-4
- Molecular formula:
- HNO3.Na
- IUPAC Name:
- sodium nitrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Physical appearance: not indicated
- Purity: not indicated
- Batch No.: not indicated
- Supplier: not indicated
Constituent 1
Test animals
- Species:
- other: dog, sheep
- Strain:
- other: Mongrel dogs
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation:
- Weight at study initiation: dogs: 13 to 55 kg
- Fasting period before study:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- > 0.125 - <= 4 h
- Concentrations:
- 0.9, 5, and 11 mg/m3
- No. of animals per sex per dose:
- 5 dogs, 6 sheep. Sex unknown.
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: NOEC
- Effect level:
- 1 - 5
- Remarks on result:
- other: 1 mg/m3 (sheep), 5 mg/m3 (dog)
Applicant's summary and conclusion
- Conclusions:
- NOEC in sheep was established to be between 1-5 mg/m³ air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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