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EC number: 209-753-1
CAS number: 592-41-6
The average results for the hyperaemia,
exfoliation and scab formation were approximately 2, which fell into the
study authors questionable grade. There was no difference in reaction
between the abraded and intact animals.
a 28-day dermal toxicity study, alpha olefin 8 was applied to the shaved
skin of six New Zealand white rabbits (3 intact and 3 abraded) at a dose
level of 0.2 millilitres for 5 days/week during a 28-day period.
The skin was ranked using a graded
system by the study authors ranging from 1 (none) to 6 (severe). The
average score for hyperaemia, exfoliation, and scab formation was
approximately 2 (considered questionable). There were no other toxicity
results reported. Therefore, no LOAEL
or NOAEL were
study received a Klimisch score of 4 and is classified as not assignable
because this study only examined one dose level, and systemic toxicity
was not evaluted.
study was selected as a supporting study because there was only was dose
level examined and systemic toxicity was not evaluated; however, the
study contains relevant and useful information, allowing this study to
qualify as a supporting study.
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