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EC number: 209-753-1
CAS number: 592-41-6
a dermal sensitisation study using Neodene 6 alpha olefin in ethanol,
Duncan Hartley guinea pigs (5 animals/sex/dose) were tested using a
patch sensitisation method. For the three weekly
initiating doses, a 1% solution Neodene 6 alpha olefin in ethanol was
applied and the primary challenge dose was also 1% Neodene 6 alpha
olefin in ethanol. Preliminary
tests indicate that the 1% concentration was appropriate for the
challenge dose, but a dose causing mild irritation should have been
chosen for the initiating dose. Reactions
were scored with a numerical grade to indicate severity. The
positive control provided the appropriate response. Body
weight gain was not affected by treatment. Neodene
6 alpha olefin caused little or no irritation after the initiation or
challenge dose and did not induce a delayed contact hypersensitivity
reaction under the conditions of the study.
This study received a Klimisch score
of 2 and is classified as reliable with restrictions because although
the study does not meet current OECD 406 guidelines, the study was well
conducted and reported.
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