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EC number: 201-052-9 | CAS number: 77-73-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The information reported here has been taken from the SIDS for 77-73-6 as we were unable to obtain this study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material: not applicable
- Analytical monitoring:
- yes
- Details on sampling:
- not reported
- Vehicle:
- yes
- Details on test solutions:
- 5 nominal concentrations (10,18, 32.4, 58.3 and 105 mg/L). Minimal amount of Tqween 80 - acetone (1:1) or DMSO HCO- 40 (9:1) is used as solubilizer
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- ATCC 22662
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Post exposure observation period:
- not reported
- Hardness:
- not reported
- Test temperature:
- not reported
- pH:
- not reported
- Dissolved oxygen:
- not reported
- Salinity:
- not reported
- Nominal and measured concentrations:
- 5 nominal concentrations 10,18, 32.4, 58.3 and 105 mg/L
- Details on test conditions:
- not reported
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 27 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Details on results:
- not reported
- Results with reference substance (positive control):
- not reported
- Reported statistics and error estimates:
- not reported
- Validity criteria fulfilled:
- not specified
- Remarks:
- insufficient data to confirm validity
- Conclusions:
- The 72 hour EC50 (growth rate) was 27mg/L and a NOEC of 18 mg/L was reported
- Executive summary:
As we were unable to obtain a copy of this report we have been unable to assess its reliability. The data reported here has been taken from the SIDS for dicylcopentadiene and can be used as part of a weight of evidence approach to assess the acute toxicity to aquatic invertebrates. The 72 hour EC50 (growth rate) was 27mg/L and a NOEC of 18 mg/L was reported.
Reference
Description of key information
The 96 hr EC50 range for the toxicity to aquatic algae, obtained from a single reliable experimental study, was 22 - >100 mg/L. The estimated EL50 and NOELR from TLM QSAR towards P. subcapitata are 6.948 mg/L and 1.331 mg /L, respectively. However, there is a MITI (1997) study for which we do not have all the study design details which reports an EC50 and NOEC of 27 mg/L and 18 mg/L, respectively. These values are in much more agreement with those published by Bentley (1976) and should be given more weight than the QSAR derived values. Therefore, the MITI values will be used in chemical safety assessment.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 27 mg/L
- EC10 or NOEC for freshwater algae:
- 18 mg/L
Additional information
Bentley et al (1976) tested the toxicity of dicyclopentadiene to three species of algae. The range of EC50 values reported within the paper was between 22 - >100 mg/L. The study followed a method similar to standard guidelines but did not include analytical confirmation of the exposure concentrations.
The OECD SIDS identified an Environmental Agency Japan test which showed the 72 hour EC50 to be 27 mg/L and the NOEC to be 18 mg/L. This study was unavailable for review but is included here as part of a weight of evidence approach together with the Bentley studies.
A QSAR result has also been included as part of the weight of evidence, which used the ECOSAR program to derive a 96 hour EC50 of 5.1 mg/L and a ChV of 2.4 mg/L, which corresponds to a NOEC value of 1.7 mg/L (calculated by ChV ÷v2 as ChV is geometric mean of NOEC and LOEC).
The aquatic toxicity of this substance was estimated using the Target Lipid Model based on methodologies described by Mcgrath et al. (2004). The estimated EL50 for this substance is 6.948 mg/L and the NOELR is 1.331 mg/L.
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