3a,4,7,7a-tetrahydro-4,7-methanoindene

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

up to 2009

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: QSAR calculation, acceptable with restrictions

Justification for type of information:

QSAR prediction

Principles of method if other than guideline:

The ECOSAR class program has been developed primarily for the evaluation of neutral organic compounds and organic classes with excess toxicity. The QSARs in the ECOSAR program are developed for chemical classes based on measured test data that have been submitted by industry or they are developed by other sources for chemicals with similar structures. Using the measured aquatic toxicity values and estimated Kow values, regression equations can be developed for a class of chemicals. Toxicity values for new chemicals may then be calculated by inserting the Kow into the regression equation and correcting the resultant value for the molecular weight of the compound.

GLP compliance:

no

Remarks:

QSAR

Specific details on test material used for the study:

N/A

Analytical monitoring:

not required

Remarks:

QSAR

Details on sampling:

N/A

Vehicle:

no

Remarks:

QSAR

Details on test solutions:

N/A

Test organisms (species):

Daphnia sp.

Details on test organisms:

N/A

Test type:

other: QSAR

Water media type:

other: QSAR

Limit test:

no

Remarks on exposure duration:

N/A

Post exposure observation period:

N/A

Hardness:

N/A

Test temperature:

N/A

pH:

N/A

Dissolved oxygen:

N/A

Salinity:

N/A

Conductivity:

N/A

Nominal and measured concentrations:

N/A

Details on test conditions:

N/A

Reference substance (positive control):

no

Remarks:

QSAR

Key result

Duration:

21 d

Dose descriptor:

other: ChV

Effect conc.:

0.812 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

not specified

Remarks on result:

other: Standard duration assumed. Based on a log Kow of 3.165

Key result

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.574 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

not specified

Remarks on result:

other: Calculated from ChV

Details on results:

N/A

Results with reference substance (positive control):

N/A

Reported statistics and error estimates:

N/A

N/A

Validity criteria fulfilled:

not applicable

Remarks:

QSAR

Conclusions:

The estimated ChV for Daphnia sp. is 0.812 mg/L, which corresponds to a NOEC of 0.574 mg/L.

Executive summary:

A QSAR value has been produced for this endpoint which provides an estimate for the long-term toxicity of the substance to aquatic invertebrates. The estimated ChV for Daphnia sp. is 0.812 mg/L, which corresponds to a NOEC of 0.574 mg/L.

The prediction is considered to fall within the model domain.

Reference 2

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

up tp 2020

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

The Target Lipid Model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. It is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Qualifier:

no guideline required

Principles of method if other than guideline:

The endpoint calculated is the LL50, EL50, and NOELR -
The narcosis target lipid model was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.

GLP compliance:

no

Remarks:

QSAR

Specific details on test material used for the study:

A logkow of 2.78 was used as input for the prediction

Analytical monitoring:

not required

Remarks:

QSAR

Details on sampling:

N/A

Vehicle:

no

Remarks:

QSAR

Details on test solutions:

N/A

Test organisms (species):

Daphnia magna

Details on test organisms:

N/A

Test type:

other: QSAR

Water media type:

other: QSAR

Limit test:

no

Remarks on exposure duration:

N/A

Post exposure observation period:

N/A

Hardness:

N/A

Test temperature:

N/A

pH:

N/A

Dissolved oxygen:

N/A

Salinity:

N/A

Conductivity:

N/A

Nominal and measured concentrations:

N/A

Details on test conditions:

N/A

Reference substance (positive control):

no

Remarks:

QSAR

Key result

Duration:

21 d

Dose descriptor:

NOELR

Effect conc.:

2.405 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

not specified

Remarks on result:

other: Result from QSAR

Details on results:

N/A

Results with reference substance (positive control):

N/A

Reported statistics and error estimates:

N/A

N/A

Validity criteria fulfilled:

not applicable

Remarks:

QSAR

Conclusions:

The estimated NOELR for this substance is 2.405 mg/L.

Executive summary:

The long-term aquatic toxicity to this substance was estimated using the Target Lipid Model based on methodologies described by Mcgrath et al. (2004, 2015). The estimated NOELR for this substance is 2.405 mg/L.

The prediction is considered to fall within the model domain.

Description of key information

There is a MITI (1997) study for which not all the study design details are reported which describes an EC₅₀ and NOEC of 4.0 mg/L and 3.2 mg/L, respectively. However, this result is higher than the short-term EC₅₀ for aquatic invertebrates (0.62 mg/L). As the original study report has not been reviewed, there is insufficient information to determine the reason for this and therefore the study has been considered not to be reliable.

A QSAR estimate has been included to provide additional data for this endpoint. The estimated 21 day ChV is 0.812 mg/L, which is equivalent to a NOEC of 0.574 mg/L. The estimated NOELR values from TLM QSAR is 2.405 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Dose descriptor:

NOEC

Effect concentration:

3.2 mg/L

Additional information

The toxicity data by the Environmental Agency of Japan (1997) has been cited in OECD SIDS but was unavailable for review. The study of chronic toxicity to Daphnia magna from Dicyclopentadiene over 21 days following OECD TG 202 (1984) showed NOEC 3.2 mg/L and LOEC 10 mg/L.

A QSAR estimate has been included to provide additional data for this endpoint. The estimated 21 day ChV is 0.812 mg/L, which is equivalent to a NOEC of 0.574 mg/L. The use of a QSAR model is considered suitable for this endpoint.

The long-term aquatic toxicity to this substance was estimated using the Target Lipid Model based on methodologies described by Mcgrath et al. (2004, 2015). The estimated NOELR for this substance is 2.405 mg/L.