Registration Dossier
Registration Dossier
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EC number: 201-204-4 | CAS number: 79-41-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- i.p.
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Use of Mathematical Models in the Study of Structure-Toxicity|Relationship of Dental Compounds: I. Esters of Acrylic and|Methacrylic Acids
- Author:
- Lawrence W.H., Bass G.E., Purcell W.P., Autian J.
- Year:
- 1 972
- Bibliographic source:
- J. Dental. Res. 51(2): 526-535 (1972)
- Reference Type:
- publication
- Title:
- Toxicological and Pharmacological actions of methacrylate monomers. I. Effects on isolated, perfused rabbit heart.
- Author:
- Mir GN, Lawrence WH, Aution J
- Year:
- 1 973
- Bibliographic source:
- J. Pharm. Sci. 62: 778-782
Materials and methods
- Principles of method if other than guideline:
- other: 10 mice / dose group (male albino ICR mice), observation time: 7 days; LD50 -dose was calculated by the Cornfield-Mantel modification of Karber's method (1950)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methacrylic acid
- EC Number:
- 201-204-4
- EC Name:
- Methacrylic acid
- Cas Number:
- 79-41-4
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methacrylic acid
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Purity not specified, typically >= 98 %
Test animals
- Species:
- mouse
- Strain:
- other: ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- No. of animals per sex per dose:
- 10 mice / dose group
- Details on study design:
- 7 day observation period
- Statistics:
- LD50 -dose was calculated by the Cornfield-Mantel modification of Karber's method (1950)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.048 other: ml/kg
- Remarks on result:
- other:
- Remarks:
- exposure route: ip
Applicant's summary and conclusion
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