Registration Dossier
Registration Dossier
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EC number: 201-204-4 | CAS number: 79-41-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- i.p.
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Use of Mathematical Models in the Study of Structure-Toxicity|Relationship of Dental Compounds: I. Esters of Acrylic and|Methacrylic Acids
- Author:
- Lawrence W.H., Bass G.E., Purcell W.P., Autian J.
- Year:
- 1 972
- Bibliographic source:
- J. Dental. Res. 51(2): 526-535 (1972)
- Reference Type:
- publication
- Title:
- Toxicological and Pharmacological actions of methacrylate monomers. I. Effects on isolated, perfused rabbit heart.
- Author:
- Mir GN, Lawrence WH, Aution J
- Year:
- 1 973
- Bibliographic source:
- J. Pharm. Sci. 62: 778-782
Materials and methods
- Principles of method if other than guideline:
- other: 10 mice / dose group (male albino ICR mice), observation time: 7 days; LD50 -dose was calculated by the Cornfield-Mantel modification of Karber's method (1950)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methacrylic acid
- EC Number:
- 201-204-4
- EC Name:
- Methacrylic acid
- Cas Number:
- 79-41-4
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methacrylic acid
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Purity not specified, typically >= 98 %
Test animals
- Species:
- mouse
- Strain:
- other: ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- No. of animals per sex per dose:
- 10 mice / dose group
- Details on study design:
- 7 day observation period
- Statistics:
- LD50 -dose was calculated by the Cornfield-Mantel modification of Karber's method (1950)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.048 other: ml/kg
- Remarks on result:
- other:
- Remarks:
- exposure route: ip
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
