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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

The 21 d NOEC and LOEC for effects of the structurally similar amides, C12-18 (even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl) on reproduction and survival rates of Daphnia magna were 0.07 and 0.24 mg/L (measured), respectively.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.07 mg/L

Additional information

A study was conducted to evaluate the effect of structurally similar amides, C12-18 (even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl) on survival and reproduction ofDaphnia magnaaccording to the OECD guideline 202, Part II, Draft 6/5/91: "Prolonged Toxicity Study withDaphnia magna: Effects on Reproduction" (updated as OECD guideline 211).

Daphnia magna(10 per dose) were exposed to the test substance in nominal concentration ranges of 0.010 - 1.0 mg/L for 21 days and effects on survival and reproduction were evaluated three times per week. The analytically determined concentrations corresponding to the nominal test concentrations of 0.10 and 0.32 mg/L were 0.07 and 0.24 mg/L, respectively.

Under the conditions of the study, the 21 d NOEC and LOEC of amides, C12-18 (even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl) were 0.07 and 0.24 mg/L (measured), respectively (Memmert U, 1995b).