Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

The weighted average log Pow of amides, C8-18 and C18-unsatd., N,N-bis(hydroxyethyl) is 3.75 at 20°C. A bioconcentration factor (BCF) calculation using this log Pow yielded a value of 65.36 L/kg w/w, suggesting low bioaccumulation potential. This assumption is supported by available toxicokinetics data. According to Section 5.1.3, amides, C8-18 and C18-unsatd., N,N-bis(hydroxyethyl) is not expected to significantly bioaccumulate because of its rapid and effective metabolism by P450 enzymes, leading to the formation of innocuous polar metabolites which are rapidly excreted (primarily) in urine.