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Description of key information

A guinea pig maximization test (Bruze et al., Contact Dermatitis, 1988) showed a sensitizing effect in one of two batches of a Cyclohexanone resin tested. The same authors also conducted a GPMT with pure Cyclohexanone which showed negative results. A mouse ear swelling test, a guinea pig maximization test and a Buehler test (Gad et al., 1986) showed no skin sensitizing properties for Cyclohexanone.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

As pure Cyclohexanone showed no sensitising properties in any of the tests available, classification is not warranted.