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EC number: 203-631-1 | CAS number: 108-94-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- BASF-internal standards; estimation of the LC50 value
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclohexanone
- EC Number:
- 203-631-1
- EC Name:
- Cyclohexanone
- Cas Number:
- 108-94-1
- Molecular formula:
- C6H10O
- IUPAC Name:
- cyclohexanone
Constituent 1
- Specific details on test material used for the study:
- purity: 99.9%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Body weight range of the animals: 185 ± 15 g
The animals were offered Herilan MRH of H. EGGERSMANN KG, Rinteln/Weser, and tap water ad libitum during the post-exposure observation period.
The animals were kept in fully air-conditioned rooms (temperature 22 ± 2°C and humidity 55 ± 5%) with a day/night rhythm of 12 hours.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- A concentration estimated on the basis of the data from the inhalation hazard test was used as a first orientating concentration. One concentration allows a no effect level to be established (0 lethality).
- Duration of exposure:
- 4 h
- Concentrations:
- 6.2 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- The body weight of the animals was checked before the beginning of the test, after 7 days and at the end of the observation period. Clinical findings and lethality were recorded daily.
At the end of the 14-day observation period, the animals were sacrificed with CO2 and were subjected to a gross-pathological examination like all other animals which had died before. - Statistics:
- Statistical evaluation of the test were done according to the binomal test (BASF SE).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6.2 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: significance level: 1%
- Mortality:
- none
- Clinical signs:
- other: Watery eye and nose secretion, mouth smearing, intermittent and accelerated breathing, apathetic, narcosis, scrubby fur. Three of 10 female animals showed alopecia. Symptoms were seen until day of killing.
- Body weight:
- No significant differences to the control group.
- Gross pathology:
- Sacrificed animals: nothing abnormal detected.
Any other information on results incl. tables
1) LC50 (4 h) for male and female animals: = > 6.2 mg/l air
2) LC50 (1 h) for male and female animals: = > 25 mg/l air*
3) LC50 (4 h) for male animals: = > 6.2 mg/l air
4) LC50 (1 h) for male animals: = > 25 mg/l air*
5) LC50 (4 h) for female animals: = > 6.2 mg/l air 6) LC50 (1 h) for female animals: = > 25 mg/l air*
* By means of converting the values of the 4-hour LC50 according to the rule of Haber C x t = k
Applicant's summary and conclusion
- Interpretation of results:
- other: The test substance is labelled with R20 (Directive 67/548/EEC)
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