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EC number: 202-704-5 | CAS number: 98-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
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- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to guideline. Full report available. However, no information of preliminary investigation (dose finding).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Maximizationtest according to Magnusson-Kligman (J Invest Dermatol 52: 268-276, 1969)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- existing study
Test material
- Reference substance name:
- Cumene
- EC Number:
- 202-704-5
- EC Name:
- Cumene
- Cas Number:
- 98-82-8
- Molecular formula:
- C9H12
- IUPAC Name:
- isopropylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Cumol
- Substance type: clear waterlike liquid
- Physical state: liquid
- Analytical purity: 99.8%
- Impurities (identity and concentrations): Not given
- Storage condition of test material: Dark, in refrigerator
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Bor: DHPW
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: F. Winkelmann, 4799 Borchen, Germany
- Age at study initiation: Not reported
- Weight at study initiation: Exposuregroup: mean weight 293.8 g, Control group: 291.6 g
- Housing:1-5 animals in Makrolon Typ IV cages
- Diet (e.g. ad libitum): G4 diet for guinea pigs, Ssniff Spezialfutter GmbH, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 4-8d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+-1 °C
- Humidity (%): 60+-5%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: From: To:
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- maize oil
- Concentration / amount:
- Intradermal induction: 10%
Epicutaneous induction: 75%
Epicutaneous challenge: 40%
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- maize oil
- Concentration / amount:
- Intradermal induction: 10%
Epicutaneous induction: 75%
Epicutaneous challenge: 40%
- No. of animals per dose:
- 20 per dose, 10 per control
- Details on study design:
- RANGE FINDING TESTS: None
MAIN STUDY
A. INDUCTION EXPOSURE
Intradermal injection
6 intradermal injections were made symetrically and simultaneously on a 4 x 6 cm shaved areal on each shoulder:
0.1 cm³ of a mixture of Freunds Adjuvant (FCA) and H2O (VE-Water), 1:1
0.1 cm³ of a 10% test solution in maize oil
0.1 cm³ of a 10% test solution in a mixture on FCA and H2O, 1:1
Topical application
One week after intradermal injection a 2 x 4 cm patch fully loaded with 75% test solution in maize oil was applied to each area and fixed for 48h.
B. CHALLENGE EXPOSURE
Topical application
Two weeks after topical induction the left flank was shaved and a 2 X 2 cm patch fully loaded with 40% test solution in maize oil was applied. The pathc was fixed for 24 h.
24h and 48h after removing of the patch the skin reaction was observed and recorded according to the Magnusson & Kligman grading scale. - Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 40%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- slight inflammation at all FCA treated injection sites (also in control group). Incrustation of injection sites after 24 h at all animals.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 40%. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: slight inflammation at all FCA treated injection sites (also in control group). Incrustation of injection sites after 24 h at all animals..
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Cumene was not sensitizing to guinea pigs in a test performed according to OECD 406.
- Executive summary:
No skin sensitisation were noted among a group of 20 female guinea pigs treated with cumene in a Magnusson-Kligman maximisation test conducted according to OECD 406. For induction 0.1 cm³ of a 10% test solution was tested and for challenge the concentration was 40%.
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