Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In the EU RAR (2001; section, page 56) it was concluded that cumene did not cause any signs of skin sensitisation in the tests conducted.


Experimental studies

No skin sensitisation was noted among a group of 20 female guinea pigs treated with cumene in a Magnusson-Kligman maximisation test conducted according to OECD Guideline 406 (see robust study summaries in IUCLDI Section 7.4.1). For induction 0.1 cm³ of a 10% test solution was tested and for challenge the concentration was 40%.


Human data

No information is available.

Migrated from Short description of key information:
As a result of an OECD Guideline study cumene is not sensitising.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
Regarding respiratory sensitisation there is no information available.

Justification for classification or non-classification