Registration Dossier
Registration Dossier
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EC number: 202-704-5 | CAS number: 98-82-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In the EU RAR (2001; section 4.1.2.5, page 56) it was concluded that cumene did not cause any signs of skin sensitisation in the tests conducted.
Experimental studies
No skin sensitisation was noted among a group of 20 female guinea pigs treated with cumene in a Magnusson-Kligman maximisation test conducted according to OECD Guideline 406 (see robust study summaries in IUCLDI Section 7.4.1). For induction 0.1 cm³ of a 10% test solution was tested and for challenge the concentration was 40%.
Human data
No information is available.
Migrated from Short description of key information:
As a result of an OECD Guideline study cumene is not sensitising.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
Regarding respiratory sensitisation there is no information available.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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