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Registration Dossier
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EC number: 202-704-5 | CAS number: 98-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data sheet with overview of serveral studies, no full test report available. However, all relevant information is given. Therefore, the study can be regarded as valid for assessment.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- 0.5 ml undiluted liquid was applied to intact and abraded skin of 6 albino rabbits. Erythema and edema were investigated after 24 and 72 h.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cumene
- EC Number:
- 202-704-5
- EC Name:
- Cumene
- Cas Number:
- 98-82-8
- Molecular formula:
- C9H12
- IUPAC Name:
- isopropylbenzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: abraded, no further information
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- No data
- Observation period:
- 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (intact and abraded skin after 24 and 72 h)
- Time point:
- other: 24 and 72 h
- Score:
- 1.84
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Draize Score
Any other information on results incl. tables
Response |
|||||||
Time of observation |
Rabbit No. |
||||||
1 |
2 |
3 |
4 |
5 |
6 |
||
Erythema |
|||||||
Intact skin |
24 h |
2 |
2 |
2 |
2 |
2 |
2 |
Intact skin |
72 h |
2 |
1 |
2 |
2 |
2 |
1 |
Abraded skin |
24 h |
2 |
2 |
2 |
2 |
2 |
2 |
Abraded skin |
72 h |
2 |
1 |
2 |
2 |
2 |
1 |
Edema |
|||||||
Intact skin |
24 h |
0 |
0 |
0 |
0 |
0 |
0 |
Intact skin |
72 h |
0 |
0 |
0 |
0 |
0 |
0 |
Abraded skin |
24 h |
0 |
0 |
0 |
0 |
0 |
0 |
Abraded skin |
72 h |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A mean score of. 1.84 (maximum score 8) was observed after 24 and 72 h. Therefore, the substance is not classified as irritating to skin according to EU criteria.
- Executive summary:
05. ml of undiluted liquid was applied to intact and abraded skin of 6 albino rabbits. Erythema and edema were investigated after 24 and 72 h. No edema were observed after 24 and 72 h (grade 0). After 24h a grade of 2 (maximum score 8) was assed for erythema both for intact and abraded skin. After 72 h the score was 1.67.
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