Cumene

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data sheet with overview of serveral studies, no full test report available. However, all relevant information is given. Therefore, the study can be regarded as valid for assessment.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1985

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Principles of method if other than guideline:

0.5 ml undiluted liquid was applied to intact and abraded skin of 6 albino rabbits. Erythema and edema were investigated after 24 and 72 h.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Cumene

EC Number:

202-704-5

EC Name:

Cumene

Cas Number:

98-82-8

Molecular formula:

C9H12

IUPAC Name:

isopropylbenzene

Test animals

Species:

rabbit

Strain:

other: Albino

Test system

Type of coverage:

not specified

Preparation of test site:

other: abraded, no further information

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Duration of treatment / exposure:

No data

Observation period:

72 h

Number of animals:

6

Results and discussion

In vivo

Results

Irritation parameter:

erythema score

Basis:

mean

Remarks:

(intact and abraded skin after 24 and 72 h)

Time point:

other: 24 and 72 h

Score:

1.84

Max. score:

8

Reversibility:

no data

Remarks on result:

other: Draize Score

Any other information on results incl. tables

				Response
	Time of observation	Rabbit No.
		1	2	3	4	5	6
Erythema
Intact skin	24 h	2	2	2	2	2	2
Intact skin	72 h	2	1	2	2	2	1
Abraded skin	24 h	2	2	2	2	2	2
Abraded skin	72 h	2	1	2	2	2	1
Edema
Intact skin	24 h	0	0	0	0	0	0
Intact skin	72 h	0	0	0	0	0	0
Abraded skin	24 h	0	0	0	0	0	0
Abraded skin	72 h	0	0	0	0	0	0

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

A mean score of. 1.84 (maximum score 8) was observed after 24 and 72 h. Therefore, the substance is not classified as irritating to skin according to EU criteria.

Executive summary:

05. ml of undiluted liquid was applied to intact and abraded skin of 6 albino rabbits. Erythema and edema were investigated after 24 and 72 h. No edema were observed after 24 and 72 h (grade 0). After 24h a grade of 2 (maximum score 8) was assed for erythema both for intact and abraded skin. After 72 h the score was 1.67.