Cumene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Internal report, no full test report available. However, all relevant information is given. Therefore, the study can be regarded as valid for assessment.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1978

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undliuted and post exposure period was 14d.

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Cumene

EC Number:

202-704-5

EC Name:

Cumene

Cas Number:

98-82-8

Molecular formula:

C9H12

IUPAC Name:

isopropylbenzene

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 h

Doses:

2000, 3160, 5010, and 7940 mg/kg bw

No. of animals per sex per dose:

1

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 3 160 mg/kg bw

Any other information on results incl. tables

	Mortalities
Dose (mg/kg)	male	female	combined
2000		0/1	0/1
3160	0/1		0/1
5010		1/1 (3 d)	1/1
7940	1/1 (2 d)		1/1

Signs of intoxication were weight loss (2 -4 days in survivors), increasing weakness, collapse, and death.

Gross autopsy: Decedents: hemorrhagic areas of the lungs, liver discoloration, enlarged gall bladder, darkened kidneys and spleen, and gastrointestinal inflammation. Survivors (14d): Visccera appeared normal.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

LD50 was >3160 mg/kg after a expusure of New Zealand albino rabbits for 24h. 1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undliuted and post exposure period was 14d.

Executive summary:

1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undiluted and post exposure period was 14d.