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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Internal report, no full test report available. However, all relevant information is given. Therefore, the study can be regarded as valid for assessment.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undliuted and post exposure period was 14d.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Cumene
EC Number:
202-704-5
EC Name:
Cumene
Cas Number:
98-82-8
Molecular formula:
C9H12
IUPAC Name:
isopropylbenzene

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
2000, 3160, 5010, and 7940 mg/kg bw
No. of animals per sex per dose:
1
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 160 mg/kg bw

Any other information on results incl. tables

Mortalities

Dose (mg/kg)

male

female

combined

2000

0/1

0/1

3160

0/1

0/1

5010

1/1 (3 d)

1/1

7940

1/1 (2 d)

1/1

Signs of intoxication were weight loss (2 -4 days in survivors), increasing weakness, collapse, and death.

Gross autopsy: Decedents: hemorrhagic areas of the lungs, liver discoloration, enlarged gall bladder, darkened kidneys and spleen, and gastrointestinal inflammation. Survivors (14d): Visccera appeared normal.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was >3160 mg/kg after a expusure of New Zealand albino rabbits for 24h. 1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undliuted and post exposure period was 14d.
Executive summary:

1 New Zealand albino rabbit (male or female) were exposed to 1 of 4 concentrations over a period of 24 h. Substance was applied undiluted and post exposure period was 14d.