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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Result and method described in suffiscient detail. Peer-reviewed publication

Data source

Reference
Reference Type:
publication
Title:
Absorption of cumene through the respiratory tract and excretion of dimethylphenylcarbinol in urin
Author:
Senczuk W, Litewka B
Year:
1976
Bibliographic source:
British Journal of Industrial Medicine 33, 100-105

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
basic toxicokinetics
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
10 healthy volunteers were exposed heads only to defined concentrations of cumene. Absorption of cumene as well as excretion of metabolite 2-phenylpropan-2-ol (=dimethylphenylcarbinol) was measured
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cumene
EC Number:
202-704-5
EC Name:
Cumene
Cas Number:
98-82-8
Molecular formula:
C9H12
IUPAC Name:
isopropylbenzene

Method

Type of population:
general
Subjects:
- Number of subjects exposed:
- Sex: 5 male, 5 female
- Age: 20-35 years old
- Race: not specified
- Demographic information: Investigations are assumed to be performed in Poland
- Known diseases: healthy according to medical examination
Ethical approval:
not specified
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
measured
Details on exposure:
Each person was exposed to three exposure concentrations at an interval of 10 day
Concentrations tested: 240, 480, and 720 mg/m3
Exposure duration: 8h, divided in two 2.5h and one 2h exposure, with a 30 min break after the exposures
Examinations:
1) Retention of cumene: concentration in inhaled air - concentration in exhaled air
2) Dimethylphenylcarbinol in urine, time of collection of urine: 2.5, 5.5, 8, 10, 12, 14, 24, 32, 40 and 48 h after start of exposure

Results and discussion

Clinical signs:
None
Results of examinations:
Retention of cumene in lungs: 64 % at 0.5 h of exposure, 45 % at the end of the exposure to vapours at 240, 480 and 720 mg/m3;
Excretion of 2-phenylpropan-2-ol in the urine: maximum was observed after 6 to 8 h of exposure, approaching zero after 48 h;
average percentage yield of the conversion of cumene into 2-phenylpropan-2-ol was 35 %.

Any other information on results incl. tables

Cumene absorbed during 8 h exposure

Sex

Cumene in chamber [mg/m3]

Mean absorbed cumene [mg]

Range
[mg]

Women

240

270.8

202.0-386.0

480

526.0

404.0-772.0

720

789.0

606.0-1158.0

Men

240

466.4

327.0-730.0

480

934.0

654.0-1460.0

720

1400.0

981.0-2190.0

Excretion of demethylphenylcarbinol

Sex

Cumene in chamber

Mean excretion [mg]

Range
[mg]

Women

100

96.6

73-130.6

300

219

151.6-343.6

600

325

201.4-447

Men

100

2.9

1.3-5.3

300

5.3

2.7-9.6

600

7.4

2.2-16.0

Applicant's summary and conclusion

Executive summary:

Absorption, metabolism and excretion 10 healthy volunteers (5 men and 5 women) aged between 20 and 35 years were exposed with their heads to 240, 480 and 720 mg cumene/m3 for 8 h periods. Retention of cumene vapours in lungs during exposure decreased from 64 % at 0.5 h of exposure to 45 % at the end of the exposure. Excretion of 2-phenylpropan-2-ol in the urine at different time intervals (2.5 to 48 h after the beginning of exposure) was correlated linearly to the amount of absorbed cumene; excretion time course: a maximum was observed after 6 to 8 h of exposure, excretion decreased after cessation of exposure approaching zero after 48 h; average percentage yield of the conversion of cumene into 2-phenylpropan-2-ol was 35 %.