Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-704-5 | CAS number: 98-82-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
There is one long-term study on effects of cumene on Daphnia magna available performed according to OECD 211/Draft and conducted under GLP. The effects on reproduction of D. magna were studied under static renewal conditions in sealed flasks. Mean measured concentrations were used for the evaluation. The NOEC was 0.35 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.35 mg/L
Additional information
The data on long-term toxicity of cumene in aquatic invertebrates is presented in EU RAR (2001) in Section 3.2.1.1 (Aquatic compartment (incl. Sediment), page 25ff).
There is one long-term study on effects of cumene on Daphnia magna available performed according to OECD 211/Draft and conducted under GLP. The effects on reproduction of D. magna were studied under static renewal conditions in sealed flasks. Mean measured concentrations were used for the evaluation.
The 21 day LC50 based on mortality of adults was > 3.0 mg/L. Production of offspring in the treated groups indicated that cumene had an effect on the reproduction at concentrations greater than 0.35 mg/L.
The study is classified as acceptable and valid and satisfies the guideline requirements for a chronic toxicity study with freshwater invertebrates. Measurements of body length of parents, observation of presence of males or ephippia were not conducted as required in the current guideline. However, as the reported NOEC for reproduction could be confirmed by QSAR modelling (EU RAR 2001 using equation of TGD Part III => EC50 0.32 mg/L), it is concluded that the NOEC of 0.35 mg/L can be used for the assessment of long-term risk for aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
