Registration Dossier
Registration Dossier
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EC number: 202-704-5 | CAS number: 98-82-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Three GLP studies were conducted according to EPA OTS 797 or OECD 202 under flow-through or static conditions in closed vessels with a freshwater and a marine species and the complete study reports are available. The lowest EC50 values based on mean measured concentrations of these studies were considered most reliable and relevant for the aquatic hazard assessment:
Freshwater: 48 h EC50 Daphnia magna 2.14 mg/L
Marine: 96 h EC50 Mysidopsis bahia 1.2 mg/L
The data indicate that there is a comparable sensitivity of freshwater and marine crustaceans.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.14 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 1.2 mg/L
Additional information
The data on short term toxicity of cumene in aquatic invertebrates is presented in EU RAR (2001) in Section 3.2.1.1 (Aquatic compartment (incl. Sediment), page 25ff).
Out of the 16 available short-term tests with aquatic invertebrates nine studies were found to be reliable. Five studies were performed with freshwater and four studies with marine species. The 24 or 48-hour LC50 values for the freshwater crustacean Daphnia magna are reported to be between 1.4 and 91 mg cumene/L and the 24-96-hour LC50 values of the marine species are between 1.2 and 110 mg/L. Chemical analysis was performed in all the nine studies. Focusing on studies with measured concentrations and standard exposure times only, three 48 hour EC50 values for D. magna are available (2.14, 4.0 and 10.8 mg/L). For marine invertebrates three EC50 values based on measured concentrations are reported: 96 hour EC50 values for Mysidopsis bahia of 1.2 and 1.3 mg/L and for EC50 values for Artemia salina of 110 mg/L (24 h) and 7.4 mg/L (48 h).
Two GLP studies were conducted according to EPA OTS 797 under flow-through conditions with a freshwater and a marine species and the complete study reports are available. The most recent study of P&D (2010) was conducted in closed vessels under static conditions. All EC50 values are based on mean measured concentrations. Out of the freshwater studies the lowest EC50 value obtained by P&D is considered most relevant. The data indicate that there is a comparable sensitivity of freshwater and marine crustaceans:
Freshwater: 48 h EC50 Daphnia magna 2.14 mg/L
Marine: 96 h EC50 Mysidopsis bahia 1.2 mg/L
For the aquatic hazard assessment both, freshwater and marine, the lowest EC50 value of 1.2 mg/L obtained with M. bahia should be used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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