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EC number: 215-524-7 | CAS number: 1328-53-6 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 74260.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations, Title 16, Section 1500.41
- Deviations:
- no
- Principles of method if other than guideline:
- 6 male albino New Zealand white rabbits were used for each trial. After clipping, the skin of the left flank of the animals was left intact, the right flank was scarified. The animals were treated for 24 h using occlusive conditions. The application site, treated with the liquid test substance, was covered with a gauze pad and wrapped with adhesive tape. After the application time, the patches/tape were removed. The primary irritation index was evaluated after 25 and 72 hours after start of application of the test material. The animals were observed for one week, at day 7 another reading was made.
- GLP compliance:
- no
Test material
- Reference substance name:
- Polychloro copper phthalocyanine
- EC Number:
- 215-524-7
- EC Name:
- Polychloro copper phthalocyanine
- Cas Number:
- 1328-53-6
- Molecular formula:
- C32HxClyCuN8
- IUPAC Name:
- [1,2,3,4,8,9,10,11,15,16,17,18,22,23,25-pentadecachloro-5,26-dihydro-29H,31H-phthalocyaninato(2-)-kappa~2~N~29~,N~31~]copper
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Analytical purity: ca. 98 %
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: at the start of the test, the animals weighed between 2.5 and 3.5 kg
- Housing: Rabbits were kept in individual cages (540 x 360 x 315 mm) or in restraining devices
- Diet: 200 g of food per animal per day (Granules Lapin "entretien", Sanders)
- Water: softened and filtrated water ad libitum, automatically given
ENVIRONMENTAL CONDITIONS
- Temperature (°C): minimum 20 °C
- Air changes: ventilation (renewal of air 12 times per hour )
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: The rabbits were clipped; the skin of the left flank was left intact ; the skin of the right flank was scarified.
- Vehicle:
- other: olive oil
- Controls:
- no
- Amount / concentration applied:
- 0.5 g pure test material, applied in paste form (mixed with olive oil)
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 6
- Details on study design:
- ADMINISTRATION/EXPOSURE
- The right flank was scarified with a sterile scalpel blade, making three parallel superficial incisions 2 cm long and 0.5 cm apart. The incisions were epidermal.
- The test substance was applied to the rabbit skin, using the right, previously scarified flank and the left intact one, at a rate of 0.5 g test substance per area and animal.
- Occlusion: A loaded gauze patch was applied to intact and scarified skin. The test substance and the gauze pads were kept in contact with the skin by a patch. Patches were then fastened to the body with adhesive tape.
- Vehicle: olive oil (0.5 g in 0.65 ml of neutralized sterilized olive oil per zone)
- Removal of the test substance: after 24 hrs
- Post exposure period: 7 days
EXAMINATION
- Observation period: after exposure at 25 h, at 72 h and 7 days
- Scoring system: readings were made of both scarified and no scarified zones, following the scale proposed by Draize. Only cutaneous reactions observed after treatment of intact skin are considered relevant for hazard assessment and are described in detail.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 4 animals
- Time point:
- other: 24-72 h
- Score:
- 1.12
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Slight desquamation was seen in 2 animals after 7 days; first reading time point was in fact 25 hours instead of 24 hours.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 5 animals
- Time point:
- other: 24-72 h
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: first reading time point was in fact 25 hours instead of 24 hours.
- Irritant / corrosive response data:
- Treatment with the test substance resulted in only one out of 6 rabbits in very slight edema after 24 h. The evaluation of erythema after 24 hours was impossible in 2 rabbits due to treatment related colouring of the skin. Very slight to well defined erythema were noticed in 4 rabbits where irritation was reversible after 7 days. Slight desquamation was seen on intact skin in 2/6 animals after 7 days.
Any other information on results incl. tables
Table 1: OECD Draize scores for edema after 24 hours exposure to the test substance:
Rabbit No. |
|
1 |
2 |
3 |
4 |
5 |
6 |
Erythema
|
25 h |
0 |
* |
1 |
* |
2 |
0 |
72 h |
1 |
* |
2 |
* |
2 |
1 |
|
7 d |
S |
§ |
0 |
0 |
0 |
S |
|
Edema
|
25 h |
0 |
0 |
0 |
0 |
1 |
1 |
72 h |
0 |
0 |
0 |
0 |
0 |
0 |
|
7 d |
0 |
§ |
0 |
0 |
0 |
0 |
|
S = slight desquamation; C = Formation of a scab without underlying necrosis |
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* = Reading of erythema was impossible on two rabbits, because of green colouration through the test material |
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§ = Rabbit No. 2 died on day 6 and was not replaced |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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