Registration Dossier
Registration Dossier
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EC number: 204-506-4 | CAS number: 121-91-5
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with REACH Annex VIII Column 2, hydrolysis studies are not necessary for substances that are readily biodegradable. Since isophthalic acid has been shown to be readily biodegradable (Point 5.2.1), a study of its hydrolysis is not required.
Key value for chemical safety assessment
Additional information
Since isophthalic acid has been shown to be readily biodegradable (Point 5.2.1), a study of its hydrolysis is not required. Under environmental conditions, hydrolysis is unlikely to make a significant contribution to the dissipation of isophthalic acid (or its salts), compared to the rate of its removal by biodegradation.
This is confirmed by the analytical data from a study of the effect of isophthalic acid on the growth of the unicellular aquatic alga Desmodesmus subspicatus (Knacker et al., 1993c): the initial measured exposure concentrations of 67.9, 298 and 1023 mg IPA-equiv/L were reduced by - on average - 17% over the course of the static, 96 -hour incubation. These data (DT50 > 4 days) provide evidence that IPA is not prone to rapid hydrolysis in the aquatic environment. Ready biodegradability test data, on the other hand, show > 60% mineralisation (CO2 production) within 5 to 7 days when IPA was dosed at 10 and 20 mg/L (Lebertz, 1991).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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