Registration Dossier
Registration Dossier
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EC number: 701-257-8 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined; no data on purity of test sample.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- Acute percutan toxicity in male and female rats.
- GLP compliance:
- not specified
- Test type:
- other: acute percutan toxicity in male and female rats.
- Limit test:
- yes
Test material
- Reference substance name:
- C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
- EC Number:
- 701-257-8
- IUPAC Name:
- C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 7 d
- Doses:
- 1.0 ml/kg bw.
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 1 055 mg/kg bw
Any other information on results incl. tables
| Dose (ml/kg bw) | sex | Timepoint of death | Toxicological result (No. of mortalities/ Animals with symptoms/ No.of animals) |
| 1.0 | male | - | 0/0/5 |
| 1.0 | female | - | 0/0/5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In this acute dermal toxicological study Mesamoll was applied once to the shaved skin of the back of male and female Wistar rats
(160 -180 g). The observation time was 7 days and during this timeperiod the test substance was not removed from the animals. No mortalities and no symptoms of toxicity could be observed. Therefore, regarding the density of Mesamoll ( 1.055 g/cm³ at 20 °C),
the LD 50 was higher than 1055 mg/kg bw.
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