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EC number: 701-257-8 | CAS number: -
Mesamoll concentration in the liver was low in all experiments (actual concentration below or slidely above LOD)
Mesamoll concentrations in fat:
Experiment 1) Cmax 22 µg/g fat (day 3); Mesamoll concentration below LOD on day 14
Experiment 2) Cmax 65 µg/g fat (first timepoint measured; day 1); elemination half-life 8 days; 20 -30% of dose eleminated by feces during the first 24 h.
Experiment 3) Mesamoll concentrations in fat increased linear over time until the end of the experiment
Experiment 4a) Mesamoll concentrations in fat increased linear over time until day 21 (ca. 235 µg/g fat) and slightly increased therafter (ca. 290 µg/g fat on day 49).
Experiment 4b) Elemination half-life: approx. 15 days
The half-life of Mesamoll in fat tissue after single oral application and repeated oral application of 1000 mg/kg was 8 days and 15 days, respectively. No accumulation was observed in the liver. 20 - 30 % of the dose was excreted in the feces within 24 h.
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