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EC number: 203-080-7 | CAS number: 103-11-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Long-term toxicity on invertebrates towards Daphnia magna with 2-ethylhexyl acrylate (OECD 211, semi-static): 21d-EC10 (growth)= 0.85mg/L ; 21d-EC10 (reproduction)= 0.91mg/L ; 21d-EC50 (mortality)= 1.6 mg/L
Results for
the structurally related n-butyl acrylate and ethyl acrylate for
long-term toxicity towards Daphnia magna :
- Data from the structurally related n-butyl
acrylate:
NOEC (reproduction) = 0.136 mg/L (Daphnia magna, OECD 211, semi-static)
- Data from the structurally related ethyl acrylate:
NOEC (reproduction) = 0.19 mg/L (Daphnia magna, EPA OTS 797.1330,
flow-through)
Key value for chemical safety assessment
Additional information
The effects of the long-term exposure of Daphnia magna to 2-ethylhexyl acrylate according to OECD Guideline 211 have been studied (Charles River, 2020).
The test was performed in a closed system with a semi-static renewal. Five test concentrations ranging from 5.6, 10, 18, 32 and 56% of a saturated solution prepared at a loading rate of 50 mg/L (TMW concentrations: 0.21, 0.44, 0.85, 1.4, 2.8 mg/L respectively) were employed. The effects values were related to TWM concentrations and are given as follows: 21d-EC10 (growth)= 0.85mg/L ; 21d-EC10 (reproduction)= 0.91mg/L ; 21d-EC50 (mortality)= 1.6 mg/L
In addition, data on the structurally related ethyl acrylate and n-butyl acrylate 21 -day chronic toxicity studies are available (BAMM 1997, BASF SE 2009).
A 21 -day Daphnia magna Reproduction Test sponsored by The Acrylate REACH Task Force was performed with n-Butyl acrylate under semi-static conditions in accordance with OECD TG 211 and GLP regulations (BASF SE, 2009). Nominal test concentrations were 0, 0.1, 0.22, 0.46, 1.0, and 2.2 mg/L. Since the mean values of n-Butyl Acrylate in M4-medium were found to be in the range of 9.3 – 80.0 % of the nominal concentrations, the effect concentrations were based on the time-weighted mean analytically detected concentrations. The most sensitive effect values were concerning reproduction: NOEC (reproduction) = 0.136 mg/L; LOEC (reproduction) = 0.457 mg/L. Survival of the parent or young daphnia was not effected, but the growth of the parent animals: NOEC (body length) = 0.457 mg/L; LOEC (body length) = 1.226 mg/L.
In addition, a 21-day chronic study with Ethyl acrylate in Daphnia magna was conducted under flow-through conditions according to EPA OTS 797.1330 (BAMM, 1997). Nominal exposure concentrations ranged from 0.38 to 6.0 mg/L. Mean measured test concentrations ranged from 0.19 to 3.2 mg/L. Effect concentrations based on measured values were as follows: EC50 was 0.5 mg/L; NOEC (reproduction) = 0.19 mg/L; LOEC (reproduction) = 0.45 mg/L and MATC (reproduction) = 0.29 mg/L.
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