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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
only 8 days instead of 14 d observation period, only males tested, lack of details on test substance
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Castor oil, hydrogenated
EC Number:
232-292-2
EC Name:
Castor oil, hydrogenated
Cas Number:
8001-78-3
Molecular formula:
C57H110O9
IUPAC Name:
1,3-bis[(12-hydroxyoctadecanoyl)oxy]propan-2-yl 12-hydroxyoctadecanoate
Details on test material:
- Name of test material (as cited in study report): hardened ricinus oil
- Analytical grade: no data
- Physical state: not stated

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Cremophor EL (BASF)
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 40% emulsion
- pH of emulsion: 5.6

MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw
Doses:
20 g/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 8 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 20 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: rat
Mortality:
No deaths occured.
Clinical signs:
other: All treated animals showed increased respiration rate, ruffled fur and diarrhoe. No further details reported.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU