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EC number: 295-405-4 | CAS number: 92045-23-3 A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study, GLP status uncertain, available as unpublished report, adequate for assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- none
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- C4-mixture
- IUPAC Name:
- C4-mixture
- Reference substance name:
- substance number
- IUPAC Name:
- substance number
- Reference substance name:
- 68467-52-8
- IUPAC Name:
- 68467-52-8
- Details on test material:
- - Name of test material (as cited in study report): C4-Gemisch
- Physical state: gas
- Analytical purity: Technical grade
- Lot/batch No.: 79/530
- no further details
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 185±15 g
- Housing: 5 per cage (individually during exposure)
- Diet: Herilan MRH diet ad libitum except during exposure
- Water: ad libitum except during exposure
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature: 22±2°C in animal room
- Humidity: 55±5%
- Air changes (per hr): not reported
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Whole-body inhalation system: stainless steel construction
- Exposure chamber volume: 200 L
- Method of holding animals in test chamber: The animals were kept singly in cages
TEST ATMOSPHERE
- Brief description of analytical method used: The nominal concentration was calculated from the amount of substance consumed and the air flow
- Quantitative determination of the vapour concentration: by gas chromatography
- From the analytically determined mass values and the sample volumes of the inhalation atmosphere the concentrations were calculated in mg/L - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal concentration 5.8 mg/L, analytical concentration 5.57 mg/L.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- no further information
- Statistics:
- The statistical evaluation of the concentration/effect relationship was carried out on the basis of the binomial test in accordance with tables of the BASF Computer Centre.
Results and discussion
- Preliminary study:
- none
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 5 800 other: mg/m3, (5.8 mg/L air)
- Exp. duration:
- 4 h
- Remarks on result:
- other: There were no effects at the highest concentration
- Mortality:
- no mortalities
- Clinical signs:
- other: none recorded
- Body weight:
- no changes in body weight of treated males or females compared with control animals 7 or 14 days after treatment
- Gross pathology:
- none reported
- Other findings:
- none reported
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 of the C4-mixture was > 5.8 mg/L (5800 mg/m3) in male and female rats.
- Executive summary:
Male and female rats were exposed to a mixture of C4 gases for 4h at 5.8 mg/L (5800 mg/m3). There were no effects and no mortalities at the highest concentration and therefore the LD50 was greater than 5800 mg/m3 (5.8 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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